Though(t)s [2023-08-14]

Though(t)s [2023-08-14]


3 min read

Brexanolone for postpartum depression

Frontiers | Allopregnanolone, the Neuromodulator Turned Therapeutic Agent:  Thank You, Next?

Another take by Psychopharmacology Institute.

  • Brexanolone is a synthetic form of allopregnagolone, a GABA modulating neurosteroid

  • The study had 216 participants, all women 18-45 with de novo MDD in their third trimester or within the first 4 weeks following delivery

  • The drug was administered via a 60-hour injection (despite a half-life of roughly 9 hours)

  • The cumulative response rate of 81.4% in BRX versus 61.7% in PLA groups

  • All the other outcomes p<0.05 better in BRX group

  • The cost of such an injection is ~$34,000 before insurance and deductions (like WTF man)

  • BRX can apparently cross BBB when administered intranasally, however, a lot is lost (16,000 ng/mg in the olfactory bulb ā‡¢ 670 ng/mg in the brain). The authors used cyclodextrin sulfobutylether-Ī²-cyclodextrin to enhance the transport

  • More on BRX

Finally, generative agents!

The long-awaited agent simulations of human behavior...tadaa...the ones that use Time-Weighted Vector Retriever. By the way, here it is.

And here's a demo which I've linked not once and not twice IIRC.

Alzheimer's and gut

  • Some of the gut bacteria were found to be more prevalent in both AD patients and, in the present study, in the so-called preclinical stage

  • One of those are Faecalibacterium prausnitzii

    Faecalibacterium Prausnitzii: An Anti-inflammatory Gut Microbe

  • A strange one as those are one of the main butyrate producers

  • Turns out it actually has a possible link to immune system activation, being increased in RA patients and decreased in Sjogren's Syndrome and Systemic Sclerosis.

  • The weird thing, yeah - F.S. is less abundant in AD than in healthy controls:

    • Still, the authors tell us that in preclinical AD, FP is more abundant (the things you do without institutional access). šŸ‘€šŸ§šŸ”Ž

      Obviously, it's detected more often; but is it more abundant on the average, and does this make real sense concerning its effects?

I wouldn't run to conclusions and causal inference here. It may well be a correlation, or an adaptive change (say, as oxidative damage increases SOD/CAT/GPx expression, tau accumulation may slightly increase the butyrate producers, or some enzymes may produce more food for that phyla, etc.)


Just a wild thought:

May the cancel culture be rooted in the solitude everyone is experiencing (actually, not)? Maybe that's more in line with interconnectedness ā‡¢ exuberance and being fast to react?

How Long it Took for Popular Apps to Reach 100 Million Users

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